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Blog — Cavalieri-Rogan

Cancer Initiation and Prevention. Prof E Cavalieri and Prof E Rogan Discoveries Explained (Basic Explanation)

3 4 catechol Quinones Cancer Prevention Cavalieri-Rogan DNA adducts

Cancer Initiation and Prevention. Prof E Cavalieri and Prof E Rogan Discoveries Explained (Basic Explanation)

Cancer Initiation and Prevention. Prof E Cavalieri and Prof E Rogan Discoveries Explained (Basic Explanation)   Prof Ercole Cavalieri and Prof Eleanor Rogan discovered that under certain circumstances the Benzene rings contained in Estrone, Estradiol and Dopamine produced a group of molecules called 3,4 Catechol Quinones. 3,4 Cathecol Quinones reacted with the DNA forming a new group of molecules that Cavalieri and Rogan called 'depurinating adducts". The depurinating adducts remove the so called purines (Adenine and Guanine) from the DNA. The progressive depletion of these important DNA components leads to genetic mutations associated to cancer. Cavalieri and Rogan analysed different types of major cancers: Breast, Ovarian, Thyroid Gland, Prostate...

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